師資
個人簡介：
南方科技大學生命科學學院與生物醫學工程系合聘助理教授，博士生導師。2012年于浙江大學光電信息工程學系獲得學士學位，2017年于香港科技大學電子及計算機工程系獲得博士學位。2017-2020年在香港科技大學繼續博士后研究工作，2020年12月入職南方科技大學。主要研究方向為生物光學成像技術的開發及其在生物醫學領域應用的交叉學科研究。近年來在Elife, Light: Science & Applications, Science Advances, Developmental Cell 等國際權威學術期刊發表論文20余篇。在各類國際會議中發表會議論文10余篇。
研究領域：
1. 自適應光學多光子熒光顯微成像技術（高時空分辨率、高組織穿透深度熒光成像）
2. 新型紅外激光誘導基因介導技術（高精度單細胞標記和譜系追蹤）
3. 多模態非線性光學成像技術（多光子熒光、二次/三次諧波、拉曼成像）及其應用
工作經歷：
2020.12 - 至今，南方科技大學生命科學學院，助理教授/博士生導師
2017-2020，香港科技大學電子及計算機系，博士后
學習經歷：
2012-2017，香港科技大學電子及計算機系，博士
2008-2012，浙江大學光電學院，學士
所獲榮譽：
2012-2017，香港科技大學博士生獎學金
2012，浙江大學百篇特優畢業論文
代表文章：
Wanjie Wu#, Sicong He#, Junqiang Wu, Congping Chen, Xuesong Li, Kai Liu, and Jianan Y. Qu*, “Long-term in vivo imaging of mouse spinal cord through an optically cleared intervertebral window”, Nature Communications, 2022.04.12, 13(1): 1-17
Wanjie Wu, Xuesong Li, Jianan Y. Qu, Sicong He*, “In vivo imaging of biological tissues with combined two-photon fluorescence and stimulated Raman scattering microscopy”, Journal of Visualized Experiments, 2021.12.20, 178, e63411
Congping Chen, Zhongya Qin, Sicong He, Shaojun Liu, Shun-Fat Lau, Wanjie Wu, Dan Zhu, Nancy Y. Ip and Jianan Y. Qu*, “High-resolution two-photon transcranial imaging of brain using direct wavefront sensing”, Photonics Research, Vol. 9, Issue 6, pp. 1144-1156 (2021)
Zhongya Qin, Congping Chen, Sicong He, Ye Wang, Kam Fai Tam, Nancy Y. Ip* and Jianan Y. Qu*, “Adaptive optics two-photon endomicroscopy enables deep brain imaging at synaptic resolution over large volumes”, Science Advances, 30 Sep 2020: Vol. 6, no. 40, eabc6521 DOI: 10.1126/sciadv.abc6521
Qixin Wei, Sicong He, Jianan Y. Quand Jiang Xia*, “Synthetic multienzyme complexes assembled on virus-like particles for cascade biosynthesis in cellulo”, Bioconjugate Chemistry, 2020, 31, 10, 2413–2420
Sicong He, JinXu, Jianan Qu* and Zilong Wen*, “Lightening the way of hematopoiesis: infrared laser-mediated lineage tracing with high spatial-temporal resolution”, Experimental hematology, V.85, P.3-7 (2020)
Miao Liu, Sicong He, Lixin Cheng, Jianan Qu and Jiang Xia*, “Phase-separated multienzyme biosynthesis”, Biomacromolecules, V.21, P.2391-2399 (2020)
Zhongya Qin#, Sicong He#, Chao Yang, Jasmine Sum-Yee Yung, Congping Chen, Christopher Kai-Shun Leung, Kai Liu and Jianan Y. Qu*, “Adaptive optics two-photon microscopy enables near-diffraction-limited and functional retinal imaging in vivo“, Light: Science & Applications, (2020)9:79, https://doi.org/10.1038/s41377-020-0317-9
Sicong He, Ye Tian, Shachuan Feng, Yi Wu, Xinwei Shen, Kani Chen, Yingzhu He, Qiqi Sun, Xuesong Li, Jin Xu*, Zilong Wen* andJianan Y. Qu*, “In vivo single-cell lineage tracing in zebrafish using high-resolution infrared laser-mediated gene induction microscopy”, eLife 2020;9:e52024, DOI: 10.7554/eLife.52024
Sicong He, Xiuqing Wei, Zhongya Qin, Congping Chen, Zhenguo Wu* and Jianan Y. Qu*, “In vivostudy of metabolic dynamics and heterogeneity in brown and beige fat by label-free multiphoton redox and fluorescence lifetime microscopy”, Journal of Biophotonics, e201960057 (2019)
Wei Kang, Tian Ma, Min Liu, Jiale Qu, Zhenjun Liu, Huawei Zhang, Bin Shi, Shuai Fu, Juncai Ma, Louis Tung Faat Lai, Sicong He, Jianan Qu, Shannon Wing-Ngor Au, Byung Ho Kang, Wilsn Chun Yu Lau, Zixin Deng, Jiang Xia*, Tiangang Liu*,”Modular enzyme assembly for enhanced cascade biocatalysis and metabolic flux.” Nature communications, 10, No. 1, 1-11 (2019)
Xuesong Li, Yan Li, Meijuan Jiang, Wanjie Wu, Sicong He, Congping Chen, Zhongya Qin, Ben Zhong Tang, Ho Yi Mak*, Jianan Y Qu*, “Quantitative Imaging of Lipid Synthesis and Lipolysis Dynamics in Caenorhabditis elegans by Stimulated Raman Scattering Microscopy“,Analytical Chemistry, 91(3), 2279-2287 (2019)
ZhongyaQin, Qiqi Sun, Yue Lin, Sicong He, Xuesong Li, Congping Chen, Wanjie Wu, Yi Luo and Jianan Y. Qu*, “New fluorescent compounds produced by femtosecond laser surgery in biological tissues: the mechanisms”, Biomedical Optics Express, Vol. 9, No. 7, 3373-90 (2018)
Sicong He, Jiahao Chen, Yunyun Jiang, Yi Wu, Lu Zhu, Wan Jin, Changlong Zhao, Tao Yu, Tienan Wang,Shuting Wu, Jianan Qu, Zilong Wen, Wenqing Zhang and Jin Xu*, “Adult zebrafish Langerhans cells arise from hematopoietic stem/progenitor cells”, eLife, 7, e36131 (2018)
Sicong He, Yitai An, Xuesong Li, Xiuqing Wei, Qiqi Sun, Zhenguo Wu*, and Jianan Y. Qu*, “In vivometabolic imaging and monitoring of brown and beige fat.” Journal of Biophotonics, e201800019 (2018)
Qiqi Sun, Zhongya Qin, Wanjie Wu, Yue Lin, Congping Chen, Sicong He, Xuesong Li, Zhenguo Wu, Yi Luo and Jianan Y. Qu*, “In vivoimaging-guided microsurgery based on femtosecond laser produced new fluorescent compounds in biological tissues”, Biomedical Optics Express, Vol. 9, No. 2, 581-90 (2018)
Ye Tian, Jin Xu, Shachuan Feng, Sicong He, Shizheng Zhao, Lu Zhu, Wan Jin, Yimei Dai, Lingfei Luo, Jianan Y Qu, Zilong Wen*, “The first wave of T lymphopoiesis in zebrafish arises from aorta endothelium independent of hematopoietic stem cells“, Journal of Experimental Medicine, jem-20170488 (2017)
Sicong He, Wenqian Xue, Zhigang Duan, Qiqi Sun, Xuesong Li, Huiyan Gan, Jiandong Huang* and Jianan Y. Qu*, “Multimodal nonlinear optical microscopy reveals critical role of kinesin-1 in cartilage development”, Biomedical Optics Express, Vol. 8, 1771-1782 (2017)
Tingzhong Li, Sicong He, Jianan Qu, Hao Wu, Shuizhu Wu, Zujin Zhao, Anjun Qin, Rongrong Hu*, Ben Zhong Tang*, “Thermoresponsive AIE polymers with fine-tuned response temperature”, Journal of Materials Chemistry C, V. 4, 2964-2970 (2016)
Jin Xu, Lu Zhu, Sicong He, Yi Wu, Wan Jin, Tao Yu, Jianan Y. Qu* and Zilong Wen*, “Temporal-spatial resolution fate mapping reveals distinct origins for embryonic and adult microglia in zebrafish”, Developmental Cell, V. 34, 632-641 (2015)
Xuesong Li, Wen Jiun Lam, Zhe Cao, Yan Hao, Qiqi Sun, Sicong He, Ho Yi Mak* and Jianan Y. Qu*, “Integrated femtosecond stimulated Raman scattering and two-photon fluorescence imaging of subcellular lipid and vesicular structures”, Journal of Biomedical Optics, V. 20, 110501 (2015)
Sicong He, Cong Ye, Qiqi Sun, Christopher K.S. Leung* and Jianan Y. Qu*, “Label-free nonlinear optical imaging of mouse retina”, Biomedical Optics Express, Vol.6, No.1 (2015)
Yan Zeng, Bo Yan, Jin Xu, Qiqi Sun, Sicong He, Jun Jiang, Zilong Wen* and Jianan Y. Qu*, “In vivononlinear optical imaging of immune responses: tissue injury and infection”, Biophysical Journal, V.107, Issue of Nov. 18 (2014)
Yan Zeng, Bo Yan, Qiqi Sun, Sicong He, Jun Jiang, Zilong Wen* and Jianan Y. Qu*, “In vivo micro-vascular imaging and flow cytometry in zebrafish using two-photon excited endogenous fluorescence”, Biomedical Optics Express, V.5, 653-663 (2014)
Qiqi Sun, Yanfeng Li, Sicong He, Chenghao Situ, Zhenguo Wu* and Jianan Y. Qu*, “Label-free multimodal nonlinear optical microscopy reveals fundamental insights of skeletal muscle development”, Biomedical Optics Express, V.5, 158-166 (2014)