師資
個(gè)人簡(jiǎn)介：
劉曉天，神經(jīng)生物學(xué)系，張明杰院士課題組研究副教授，碩士生導(dǎo)師。本科畢業(yè)于中國(guó)科學(xué)技術(shù)大學(xué)生命科學(xué)學(xué)院，隨后在香港科技大學(xué)先后畢業(yè)于生物化學(xué)系，生物醫(yī)藥工程系，獲得碩士，博士學(xué)位。2020年9月加入生命科學(xué)學(xué)院，張明杰院士課題組。
研究領(lǐng)域：
1. 蛋白質(zhì)機(jī)器的三維結(jié)構(gòu)解析及其生物學(xué)功能研究；
2. 生物大分子自組裝的分子機(jī)制；
3. 蛋白質(zhì)凝聚體的解碼與編程。
工作經(jīng)歷：
劉曉天，博士，碩士生導(dǎo)師。2020年9月加入生命科學(xué)學(xué)院，張明杰院士課題組。先后擔(dān)任研究助理教授，研究副教授。主要從事生物大分子結(jié)構(gòu)與功能的研究。
學(xué)習(xí)經(jīng)歷：
2003-2008，中國(guó)科學(xué)技術(shù)大學(xué)，生物技術(shù)，學(xué)士；
2013-2015，香港科技大學(xué)，生物化學(xué)，碩士；
2015-2019，香港科技大學(xué)，生物醫(yī)藥工程，博士。
所獲榮譽(yù)：
Hong Kong Technology Talent Scheme Postdoctoral Hub for ITF, 020
Chan Tak Kei & Wong Kwai Ying Bioengineering Student Research Award, 2019
HKJEBN Scholarship for Talents, 2016-2019
代表文章：
1. Xinlin Hu#, Ping Yang#, Changdong Chai, Jia Liu, Huanhuan Sun, Yanan Wu, Mingjie Zhang, Min Zhang*, Xiaotian Liu* & Hongjun Yu*. (2023) “Structural and mechanistic insights into fungal β-1,3-glucan synthase FKS1” Nature. 616(7955):190-198.
2. Shuang Fu#, Wei Shi#, Tingdan Luo, Yingchuan He, Lulu Zhou, Jie Yang, Zhichao Yang, Jiadong Liu, Xiaotian Liu, Zhiyong Guo, Chengyu Yang, Chao Liu, Zhen-li Huang, Jonas Ries, Mingjie Zhang, Peng Xi, Dayong Jin & Yiming Li*. (2023) “Field-dependent deep learning enables high-throughput whole-cell 3D super-resolution imaging” Nat Methods. 20(3):459-468.
3. Yanan Wu#, Min Zhang#, Yizheng Yang#, Xuyang Ding, Ping Yang, Kai Huang, Xinlin Hu, Mingjie Zhang, Xiaotian Liu* & Hongjun Yu*. (2022) “Structures and mechanism of chitin synthase and its inhibition by antifungal drug Nikkomycin Z” Cell Discov. 8(1): 129.
4. Bojing Jiang#, Xiaotian Liu#, Chao Yang#, Zhongguang Yang, Jiren Luo, Songzi Kou, Kai Liu, and Fei Sun*. (2020) “Injectable, photoresponsive hydrogels for axon regeneration enabled by metal-directed protein assembly” Science Advances. v. 6 (41): eabc4824.
5. Songzi Kou, Xin Yang, Zhongguang Yang, Xiaotian Liu, SV Wegner, Fei Sun*. (2019) “Cobalt-Cross-Linked, Redox-Responsive Spy Network Protein Hydrogels” ACS Macro Letters. 8(7):773-778.
6. Xiaotian Liu, Xin Yang, Zhongguang Yang, Jiren Luo, X Tian, Kai Liu, Songzi Kou, Fei Sun*. (2018) “Versatile engineered protein hydrogels enabling decoupled mechanical and biochemical tuning for cell adhesion and neurite growth” ACS Applied Nano Materials. 1(4):1579-1585.
7. A Tyagi, Xiaotian Liu, I Abidi, Z Gao, B Park, X Zeng, X Ou, A Cagang, M Zhuang, M Hossain, K Zhang, L Weng, F Sun, Z Luo*. (2018) “Modular functionalization of crystalline graphene by recombinant proteins: a nanoplatform for probing biomolecules” Nanoscale. 10(47):22572-22582.
8. Jiren Luo, Xiaotian Liu, Zhongguang Yang, Fei Sun*. (2018) “Synthesis of Entirely Protein-Based Hydrogels by Enzymatic Oxidation Enabling Water-Resistant Bioadhesion and Stem Cell Encapsulation”. ACS Applied Bio Materials. 1(5):1735-1740.
9. Wei Zhiyi#, Xu Zhiwen#, Liu Xiaotian, Lo WS, Ye F, Lau CF, Wang F, Zhou JJ, Nangle LA, Yang XL, Zhang Mingjie*, Schimmel P*. (2016) “Alternative splicing creates two new architectures for human tyrosyl-tRNA synthetase” Nucleic Acids Res. 44(3):1247-55.
10. Wei Zhiyi#, Liu Xiaotian#, Yu Cong, Zhang Mingjie*. (2013) “Structural basis of cargo recognitions for class V myosins” PNAS. 110(28):11314-9.
11. Wu Minhao#, Tao Yue#, Liu Xiaotian, Zang Jianye*. (2013) “Structural basis for phosphorylated autoinducer-2 modulation of the oligomerization state of the global transcription regulator LsrR from Escherichia coli” JBC. 288(22):15878-87.
12. Liu Xiaotian, Wu Minhao, Sun Demeng, Zang Jianye*. (2010) “Cloning, purification, crystallization and preliminary crystallographic analysis of LsrR from Escherichia coli” Acta F. 66(Pt 8):913-5.
#Co-first author, *Correspondence